Cyclic dipeptide, furan, furanone, and butenolide derivatives from marine-derived fungus <i>Aspergillus</i> sp. HL24: Cyclic dipeptide, furan, furanone, and butenolide derivatives from marine-derived fungus Aspergillus sp. HL24

Ninh Thi Ngoc; Le Thi Vien; Pham Thi Cham; Tran Thi Hong Hanh; Khac Thanh Tung Ninh; Do Thi Thao; Nguyen Xuan Cuong; Nguyen Hoai Nam

doi:10.15625/1859-3097/23413

Author affiliations

Authors

Ninh Thi Ngoc Institute of Chemistry, VAST, Vietnam
Le Thi Vien Institute of Chemistry, VAST, Vietnam
Pham Thi Cham Institute of Chemistry, VAST, Vietnam
Tran Thi Hong Hanh Institute of Chemistry, VAST, Vietnam
Ninh Khac Thanh Tung Institute of Chemistry, VAST, Vietnam; College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
Do Thi Thao Institute of Biology, VAST, Vietnam
Nguyen Xuan Cuong Institute of Chemistry, VAST, Vietnam
Nguyen Hoai Nam Institute of Chemistry, VAST, Vietnam

DOI:

https://doi.org/10.15625/1859-3097/23413

Keywords:

Aspergillus, marine-derived fungus, cytotoxic activity

Abstract

Using various chromatographic experiments, one cyclic dipeptide (1), one furan (2), one pyranone (3) and two butenolide (4 and 5) derivatives were isolated from the marine-derived fungus Aspergillus sp. HL24. Their chemical structures were elucidated on the basis of detailed analysis of the 1D (¹H NMR and ¹³C NMR) and 2D (HSQC and HMBC) NMR spectroscopic data in comparison with the literature values. The cytotoxic activities of compounds 1–5 were evaluated on two human cancer cell lines as Hep-G2 (liver) and A549 (lung). However, these compounds did not show significant cytotoxicity (IC₅₀ > 100 µM) against both cell lines.

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